Bloom's mother, Sonia Constance Josephine (née Copeland), was born in Calcutta, India, the daughter of Francis John Copeland, a physician and surgeon, and Betty Constance Josephine (née Walker).
Bloom subsequently established himself as a leading man in Hollywood films such as Balian de Ibelin in Ridley Scott's Kingdom of Heaven (2005) and Elizabethtown (2005).
He made his professional stage debut in West End's In Celebration at the Duke of York's Theatre in London in 2007 and starred in a Broadway adaption of Romeo and Juliet in 2013.
Orlando initially believed that his biological father was his mother's husband, the Jewish South African-born anti-Apartheid novelist Harry Saul Bloom (1913–81), who died when Bloom was four years old.
However, when he was thirteen, Bloom's mother revealed to him that his biological father was actually Colin Stone, his mother's partner and family friend.
In 2006, Bloom starred in sequel Pirates of the Caribbean: Dead Man's Chest and in the independently made Haven, of which he was also executive producer.